Bookcover of Staphylococcal Infection Delays Thrombus Resolution
Booktitle:

Staphylococcal Infection Delays Thrombus Resolution

A Mouse Model

VDM Verlag Dr. MŸller Aktiengesellschaft & Co. KG (2008-07-01 )

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ISBN-13:

978-3-639-04875-9

ISBN-10:
363904875X
EAN:
9783639048759
Book language:
English
Blurb/Shorttext:
Chronic thromboembolic pulmonary hypertension (CTEPH) results from single or recurrent pulmonary thromboemboli arising from sites of venous thrombosis. In patients with CTEPH thromboemboli do not resolve, but rather they form endothelialized, fibrotic obstructions of the pulmonary vascular bed. Mechanisms underlying thrombus organisation are poorly understood. Because of the observation that infected intravenous leads enhance the likelihood of CTEPH, the hypothesis that bacterial infection causes a failure of thrombus resolution, has been tested. A mouse model of venous thrombus formation was employed to investigate thrombus resolution in the absence and in presence of low doses staphylococcus aureus. On days 3, 7, 14 and 28 after thrombus induction, animals were sacrificed, thrombi were harvested, fixed and embedded in paraffin. Thrombi of infected mice were larger than controls. Furthermore, fibrosis markers showed a different expression pattern.
Publishing house:
VDM Verlag Dr. MŸller Aktiengesellschaft & Co. KG
By (author) :
Bassam Redwan
Number of pages:
56
Published at:
2008-07-01
Stock:
Available
Category:
Medicine
Price:
49.00 €
Keywords:
Medicine, Thrombosis, Pulmonary hypertension, infection

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