Bookcover of (R)-3-hydroxycarboxylic acids from bacterial polyhydroxyalkanoates
Booktitle:

(R)-3-hydroxycarboxylic acids from bacterial polyhydroxyalkanoates

Production of (R)-3-hydroxycarboxylic acids and investigation of the physiological role of polyhydroxyalkanoate degradation

Südwestdeutscher Verlag für Hochschulschriften (2009-05-07 )

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ISBN-13:

978-3-8381-0692-2

ISBN-10:
383810692X
EAN:
9783838106922
Book language:
German
Blurb/Shorttext:
In this thesis (R)-3-hydroxycarboxylic acids (HA) from bacterial polyhydroxyalkanoates (PHA) were investigated, regarding their biotechnological production as well as intracellular processes of their formation and degradation. An innovative bioprocess to provide HA as fine chemicals for further applications is presented. The method is straightforward, easy to handle and results in high yields (introduced in chapters 2-4). Following the observations of this study, attempts to scale up the process seemed possible and potential applications of HA remain topics of research. The underlying mechanisms of PHA degradation were also addressed, including issues of physiological advantages of HA excretion for cells (chapter 5) and characterization of enzymes having HA as substrates (chapters 6 and 7). Even though some aspects of PHA metabolism were clarified for P. putida GPo1, many details about intracellular PHA degradation remain obscure and require further experiments and discussion. Knowledge about their molecular context in the bacterial cell is crucial for efficient PHA and HA production.
Publishing house:
Südwestdeutscher Verlag für Hochschulschriften
Website:
https://www.svh-verlag.de
By (author) :
Katinka Ruth
Number of pages:
152
Published at:
2009-05-07
Stock:
Available
Category:
Biochemistry, biophysics
Price:
69.90 €
Keywords:
PHA, Polyhydroxyalkanoates, hydroxycarboxylic acids, Pseudomonas putida, Degradation, acyl-CoA synthetase, depolymerase, polyhydroxyalkanoates, degradation

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