Bookcover of Lipophilic drugs(Statins)and cardiovascular diseases in albino rats
Booktitle:

Lipophilic drugs(Statins)and cardiovascular diseases in albino rats

lipophilic drugs (Statins) and cardiovascular diseases in male albino rats

LAP LAMBERT Academic Publishing (2012-06-17 )

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ISBN-13:

978-3-659-13073-1

ISBN-10:
3659130737
EAN:
9783659130731
Book language:
English
Blurb/Shorttext:
In this study, the physiological and molecular effects of two cholesterol lowering agents , synthetic statin (atorvastatin) and natural statin (simvastatin) on diabetic and hypercholesterolemic adult male Wistar albino rats (Rattus norvegicus)at two doses, 10 and 40 mg/kg, for 8 weeks was investigated. Other physiological parameters were evaluated under this investigation, like: glucose, urea, uric acid, creatinine, total protein, albumin, globulin, A/G ratio, total, direct and indirect billirubin) To assess the beneficial effect of the drugs on liver genomic DNA, the (RE) analysis with 5 restriction endonucleases manifested variations in DNA digestion patterns in diabetic and hypercholesterolemic rats treated with atorvastatin and simavstatin. Such variation reflects and clarifies a restoration and repairing effect of statin on rat liver DNA in diabetic and hypercholesterolemic rats.
Publishing house:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
By (author) :
Mohamed Sayed Salama, Nadia Mohamed El-Beih, Enas Ali El-Husseny
Number of pages:
252
Published at:
2012-06-17
Stock:
Available
Category:
Zoology
Price:
79.00 €
Keywords:
Cholesterol, DNA, liver, Kidney, Atorvastatin, Alloxan, Simvastatin, Restriction endonucleases, Albino rat.

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