Bookcover of Hepatotoxic evaluation in albino rats exposed to ceftriaxone
Booktitle:

Hepatotoxic evaluation in albino rats exposed to ceftriaxone

Hepatotoxicity of ceftriaxone in rats

LAP LAMBERT Academic Publishing (2012-04-04 )

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ISBN-13:

978-3-8484-9640-2

ISBN-10:
3848496402
EAN:
9783848496402
Book language:
English
Blurb/Shorttext:
The hepatotoxic effect and biochemical alterations induced by ceftriaxone were investigated in rats following repeated intramuscular injections of 180 and 360 mg/kg b.wt. daily for five consecutive days. Ceftriaxone produced significant increase in serum concentrations of liver enzymes (AST and ALT), total bilirubin, cholesterol, Tg and LDL-cholesterol. Ceftriaxone also caused significant decrease in albumin and HDL-cholesterol. Ceftriaxone injection in the tested doses caused histopathological changes in liver. The severity of these changes was dose dependant. In conclusion, the hepatic functions should be monitored and/or the dose should be adjusted during ceftriaxone therapy.The liver is sometimes referred to as the “great chemical factory” of the body, because the body depends on the liver to regulate, synthesize, store and secrete many important proteins, nutrients, chemical and to purify and clear toxin or unneeded substance from the body. Liver is considered to be the center of metabolic transformation of drugs and other toxins entering from the gastrointestinal tract as such the normal or healthy functioning of the liver determines the health status of an individual.
Publishing house:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
By (author) :
Mohamed Aboubakr, Mossad Elsayed, Ashraf Elkomy
Number of pages:
72
Published at:
2012-04-04
Stock:
Available
Category:
Veterinary medicine
Price:
49.00 €
Keywords:
rat, Histopathology, hepatotoxicity, biochemical, Ceftriaxone

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