Bookcover of Effects of Demethylation on the Expression of Foxp3 in T-reg Cells
Booktitle:

Effects of Demethylation on the Expression of Foxp3 in T-reg Cells

An investigation on how epigenetic regulation of Foxp3 may influence the stability of regulatory T cell function

LAP LAMBERT Academic Publishing (2014-02-05 )

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ISBN-13:

978-3-659-49509-0

ISBN-10:
3659495093
EAN:
9783659495090
Book language:
English
Blurb/Shorttext:
CD4+Foxp3+ regulatory T cells (TREG) are pivotal in the maintenance of immune tolerance to self-antigens and act as regulators of autoimmune reactions. There are two subsets of TREG: naturally occurring (nTREG) which develop in the thymus and inducible (iTREG) which are generated from conventional Foxp3- effector T cells (TCONV) in the periphery or in vitro. While both subsets require Foxp3 expression to function, iTREG cells gradually downregulate Foxp3 in vitro and lose their suppressive capabilities. In contrast, nTREG cells show constitutive Foxp3 expression and demonstrate stable suppressive function in vitro. Recent studies reveal a region of the Foxp3 locus that is differentially methylated between nTREG and iTREG. The methylation-sensitive region, known as the TREG-specific demethylated region (TSDR), is completely unmethylated in nTREG, partially methylated in iTREG, and heavily methylated in TCONV, suggesting that differential methylation patterns of the TSDR may account for unstable Foxp3 expression in iTREG. In this study, we investigate whether inhibition of DNMTs and thus methylation, impacts the stability of Foxp3 expression in cultured iTREG.
Publishing house:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
By (author) :
Edmund Yao
Number of pages:
92
Published at:
2014-02-05
Stock:
Available
Category:
Biochemistry, biophysics
Price:
54.90 €
Keywords:
System, Regulatory, T cells, Autoimmune, immune, CD4, Methylation, DNMT, azacytidine, scurfy, IPEX, TGF, ntreg, itreg, RG108, immunology, Autoimmunity, Regulation, inhibition, Foxp3, methyltransferase, demethylation, treg

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