Bookcover of Development of Novel Peptide Inhibitors to BAG-1
Booktitle:

Development of Novel Peptide Inhibitors to BAG-1

Applications of Peptidyl-Biomimetics to reduce and eliminate tumor resistance to chemotherapy

LAP LAMBERT Academic Publishing (2014-02-26 )

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ISBN-13:

978-3-8465-4302-3

ISBN-10:
3846543020
EAN:
9783846543023
Book language:
English
Blurb/Shorttext:
One of the most challenging aspects of treating tumors with chemotherapy is that the tumors can develop a resistance to the chemotherapy and survive while the rest of the healthy, non-cancerous cells perish. Higher doses of chemotherapy deliver fewer positive results and at the expense of greater side effects. The purpose of this book it to identify and exploit a weakness at the molecular level of the anti-apoptotic pathway utilized by cancer cells to turn off the "triggered cell death" mechanism of apoptosis and survive chemotherapy. We specifically target the interaction between the anti-apoptotic protein Bcl-2 Associated Athanogene (BAG-1) and the 70-kilodalton Heat Shock Protein (HSP-70) that is suspected of driving the chemotherapeutic resistance, and seek to disrupt that interaction via peptidyl-biomimetically engineered peptides that are predicted via an in-house computational software named 'Contact" and experimentally verified via Biacore (c) binding assays.
Publishing house:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
By (author) :
Jonathan Brunn
Number of pages:
92
Published at:
2014-02-26
Stock:
Available
Category:
Biochemistry, biophysics
Price:
54.90 €
Keywords:
Peptidyl-Biomimetics, apoptosis peptide t, therapeutic inhibitor antiapoptosis, mechanism of apoptosis, Tumors, Chemotherapy, Cancer

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