- Natural-, Medical- , Computer Sciences, Technology
- Biology
- Biochemistry, biophysics
- Development of Novel Peptide Inhibitors to BAG-1
- Bookcover of Development of Novel Peptide Inhibitors to BAG-1
- Booktitle:
-
Development of Novel Peptide Inhibitors to BAG-1
Applications of Peptidyl-Biomimetics to reduce and eliminate tumor resistance to chemotherapy
LAP LAMBERT Academic Publishing (2014-02-26 )
eligible for voucher
- ISBN-13:
978-3-8465-4302-3
- ISBN-10:
- 3846543020
- EAN:
- 9783846543023
- Book language:
- Blurb/Shorttext:
- One of the most challenging aspects of treating tumors with chemotherapy is that the tumors can develop a resistance to the chemotherapy and survive while the rest of the healthy, non-cancerous cells perish. Higher doses of chemotherapy deliver fewer positive results and at the expense of greater side effects. The purpose of this book it to identify and exploit a weakness at the molecular level of the anti-apoptotic pathway utilized by cancer cells to turn off the "triggered cell death" mechanism of apoptosis and survive chemotherapy. We specifically target the interaction between the anti-apoptotic protein Bcl-2 Associated Athanogene (BAG-1) and the 70-kilodalton Heat Shock Protein (HSP-70) that is suspected of driving the chemotherapeutic resistance, and seek to disrupt that interaction via peptidyl-biomimetically engineered peptides that are predicted via an in-house computational software named 'Contact" and experimentally verified via Biacore (c) binding assays.
- Publishing house:
- LAP LAMBERT Academic Publishing
- Website:
- https://www.lap-publishing.com/
- By (author) :
- Jonathan Brunn
- Number of pages:
- 92
- Published at:
- 2014-02-26
- Stock:
- Available
- Category:
- Biochemistry, biophysics
- Price:
- 54.90 €
- Keywords:
- Peptidyl-Biomimetics, apoptosis peptide t, therapeutic inhibitor antiapoptosis, mechanism of apoptosis, Tumors, Chemotherapy, Cancer
