Clavulanic Acid
beta-lactamase, Beecham, Antibiotics, antibiotic, aphrodisiac
978-613-5-83268-6
6135832689
76
2011-09-16
29.00 €
eng
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Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Clavulanic acid (rINN) is a beta-lactamase inhibitor (marketed by GlaxoSmithKline, formerly Beecham) combined with penicillin group antibiotics to overcome certain types of antibiotic resistance. It is used to overcome resistance in bacteria that secrete beta-lactamase, which otherwise inactivates most penicillins. In its most common form, the potassium salt potassium clavulanate is combined with amoxicillin (co-amoxiclav [brand name Augmentin] or the veterinary formulation Synulox from Pfizer, or [Clavulox]) or ticarcillin. It is also under investigation as a NAALADase inhibitor with purported antidepressant and aphrodisiac properties, as in page 15 of this patent. Clinical trials are underway on XR ("Serdaxin") and IR ("RX-10100", "Zoraxel") formulations by Rexahn in the US.
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Chemistry
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