Bookcover of CD4+CD25high T-Cells in Juvenile Lupus and Rheumatoid Arthritis
Booktitle:

CD4+CD25high T-Cells in Juvenile Lupus and Rheumatoid Arthritis

Quantification of CD4+CD25high T- cells in the Peripheral Blood of Children with SLE and JRA

LAP LAMBERT Academic Publishing (2012-07-19 )

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ISBN-13:

978-3-659-18722-3

ISBN-10:
3659187224
EAN:
9783659187223
Book language:
English
Blurb/Shorttext:
CD4+CD25high nTregs are the major subset of T-cells that maintain immune tolerance.Breaking self-tolerance results in autoimmunity.This book gives you a simplified review about the immune tolerance and when it is failed resulting in autoimmune diseases using SLE and JRA as examples. In addition, a chapter of possible therapeutic modalities of nTregs is included. The practial part of the book was a study of the percentages of CD4+CD25high nTregs in the peripheral blood using flowcytometry for 40 children and adolescents with pediatric SLE and JRA in addition to 20 healthy subjects as a control group. The study demonstrated the relationship of nTregs to the disease status and corticosteroids. The variation of the percentage of nTregs with the age and duration of the disease in each group was as well emphasized. At the end of the book, we drew a conclusion and recommendations for further studies in this field.
Publishing house:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
By (author) :
Dalia El-Ghoneimy, Zeinab Awad, Gehan Mostafa
Number of pages:
180
Published at:
2012-07-19
Stock:
Available
Category:
Other
Price:
68.00 €
Keywords:
JRA, immune tolerance, Regulatory T-cells, SLE

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