Bookcover of Anion Receptors Based on Ion Pairing and Hydrogen Bonding
Booktitle:

Anion Receptors Based on Ion Pairing and Hydrogen Bonding

From Nitrate to Naproxen

LAP LAMBERT Academic Publishing (2011-06-22 )

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ISBN-13:

978-3-8443-8424-6

ISBN-10:
3844384243
EAN:
9783844384246
Book language:
English
Blurb/Shorttext:
This thesis reports the design and synthesis of guanidinium-based receptors as multiple hydrogen bond hosts for molecular recognition of anions with a special emphasis on small anions such as nitrate and the anti-inflammatory drug Naproxen.Despite its significant involvement in environmental pollution, little attention has been given to nitrate by supramolecular chemists. This books reports the design of several macrocycles combining a guanidinium and two urea moieties for an optimal complement of size, charge and binding sites to nitrate. Naproxen is the only Non-Steroidal Anti-Inflammatory drug (NSAID) marketed as a pure enantiomer. The industrial preparation of the drug involves the synthesis of the racemic acid followed by a resolution process to afford the desired compound (resolution accounts for two thirds of the production costs). Here, we propose as an alternative the use of a physical separation method (liquid-liquid extraction) employing a chiral receptor.
Publishing house:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
By (author) :
Pascal Blondeau
Number of pages:
196
Published at:
2011-06-22
Stock:
Available
Category:
Organic chemistry
Price:
68.00 €
Keywords:
anion recognition, enantiorecognition, supramolecular chemistry

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