Terminal Complement Pathway Deficiency
Complement membrane attack complex, Complement component 5, Complement component 6, Complement component 7
978-613-9-25691-4
6139256917
60
2012-01-01
29.00 €
eng
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Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Terminal complement pathway deficiency is a genetic condition affecting the complement membrane attack complex (MAC). It involves deficiencies of C5, C6, C7, and C8. (While C9 is part of the MAC, and deficiencies have been identified, it is not required for cell lysis.) People with this condition are prone to infection. Vaccination may be recommended. Initial complement tests often include C3 and C4, but not C5 through C9. Instead, the CD50 result may play a role in diagnosis: if the CD50 level is low but CD3 and CD4 are normal, then analysis of the individual terminal components may be warranted.
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