DNA Polymerase Lambda
978-613-6-37299-0
6136372991
80
2011-07-03
34.00 €
eng
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Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. DNA polymerase lambda, also known as POLL, is a protein that, in humans, is encoded by the POLLA gene.Pol λ is a member of the X family of DNA polymerases. It is thought to resynthesize missing nucleotides during non-homologous end joining, a pathway of DNA double-strand break repair. The crystal structure of pol λ shows that, unlike the DNA polymerases that catalyze DNA replication, pol λ makes extensive contacts with the 5' phosphate of the downstream DNA strand. This allows the polymerase to stabilize the two ends of a double-strand break and explains how pol λ is uniquely suited for a role in non-homologous end joining. In addition to NHEJ, pol λ can also participate in base excision repair, where it provides backup activity in the absence of Pol β.
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Зоология
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