Capa do livro de Synthesis and biological testing of 1-adamantyl derivatives
Título do livro:

Synthesis and biological testing of 1-adamantyl derivatives

Different synthetic methods and biological evaluation of adamantane containing derivatives

VDM Verlag Dr. Müller (2010-04-01 )

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ISBN- 1 3:

978-3-639-24670-4

ISBN- 1 0:
3639246705
EAN:
9783639246704
Idioma do livro:
Inglês
Anotações e citações/ texto breve:
Several adamantane derivatives have long been known for diverse biological properties, mainly as antiviral, antibacterial, antifungal and anti-inflammatory agents. adamantyl derivatives were recently reported to possess 11-HSD1 inhibitory activities. In addition, 1,2,4-triazole and 1,3,4-thiadiazole were reported to constitute the pharmacologically active moiety of several compounds. On these bases new series of 1-adamantyl derivatives, in which the adamantyl moiety was attached to 1,2,4-triazole, 1,2,4-triazolo[3,4-b][1,3,4]thiadiazole or 1,3,4-thiadiazole nucleus, have been synthesized as potential bioactive agents All the synthesized compounds were tested for their in vitro growth inhibitory activity against a panel of standard strains of pathogenic microorganism including Gram-positive bacteria, Gram-negative bacteria and the yeast-like pathogenic fungus Candida albicans. In addition, the acute anti-inflammatory activity of a representative compounds was determined in vivo following the carrageenan-induced paw oedema method in rats.
Editora:
VDM Verlag Dr. Müller
Website:
http://www.vdm-verlag.de
Por (autor):
Ebtehal AlAbdullah, Dr. Ali, Dr. Ihsan
Número de páginas:
176
Publicado em:
2010-04-01
Stock:
Disponível
Categoria:
Farmácia
Preço:
68 €
Palavras chave:
((Adamantyl-1, 2, 4-triazole)), 4-triazolo[3, 4-b][1, 3, 4] thiadiazole)), 4-thiadiazole)), microwave synthesis, Antiviral, antibacterial, antiinflamatory, 11-HSD1 inhibitory activities, antifungal, 4] thiadiazole))

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