Capa do livro de Palladium(0)-Catalyzed Cross-Coupling and Cyclocondensations Reactions
Título do livro:

Palladium(0)-Catalyzed Cross-Coupling and Cyclocondensations Reactions

Site-selective Palladium-Catalyzed Cross-Coupling Reactions and Synthesis of N,O-Heterocycles by Cyclocondensations of Hydrazone and Oxime Dianions

VDM Verlag Dr. Müller (2011-08-28 )

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ISBN- 1 3:

978-3-639-37649-4

ISBN- 1 0:
3639376498
EAN:
9783639376494
Idioma do livro:
Inglês
Anotações e citações/ texto breve:
The main part of this book is the efficient regioselective synthesis of functionalized heterocycles (furans, pyrroles, thiophenes, selenophenes) based on the palladium(0)-catalyzed cross-coupling and metal-halide exchanged reactions of brominated heterocycles. The study of the efficient methodologies (regioselectivities, optimization of condition including catalysts, solvent, temperature …) to functionalize them to give a valuable synthetic procedure for the synthesis of pharmacologically relevant products and of useful intermediates for further synthetic transformations. These simple methodologies were applied to synthesize the sulfur- analogues of pyrrole natural product, such as ningaline A. The second part is oriented synthesis of N,O-heterocycles. The convenient approach to synthesized pyrazole-3-carboxylates and pyrazole-1,5- dicarboxylates by one-pot cyclization of hydrazone dianions with diethyl oxalate and 6-iodo- and 6- bromomethyl-5,6-dihydro-4H-1,2-oxazines by condensation of dilithiated acetophenone-oximes with allylbromide and subsequent regioselective iodine- or NBS-mediated cyclization were shown.
Editora:
VDM Verlag Dr. Müller
Website:
http://www.vdm-verlag.de
Por (autor):
Tung Thanh Dang
Número de páginas:
160
Publicado em:
2011-08-28
Stock:
Disponível
Categoria:
Química orgânica
Preço:
59 €
Palavras chave:
furans, thiophenes, selenophenes, pyrroles, carbazoles, Oxazoles, pyrazoles, heterocycles, Cross-Coupling, Palladium, Regioselectivity, catalysis, dianion, hydrazoles, one-pot reactions

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