Capa do livro de Gene Delivery by Protein-Polymer Nanoconjugates
Título do livro:

Gene Delivery by Protein-Polymer Nanoconjugates

LAP LAMBERT Academic Publishing (2019-09-10 )

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ISBN- 1 3:

978-620-0-23222-9

ISBN- 1 0:
6200232229
EAN:
9786200232229
Idioma do livro:
Inglês
Anotações e citações/ texto breve:
In this book, we explore the potential applications of protein-polymer nanoconjugates in gene delivery. Conjugation of human serum albumin (HSA), bovine serum albumin (BSA) and beta-lactoglobulin (β-LG) with chitosan (carbohydrates) and PAMAM (dendrimers) of different sizes were used to transport DNA and RNA. Thermodynamic analysis showed that the conjugation of DNA and RNA to protein-polymer nanoparticles occurred via hydrophilic, hydrophobic, H-bonding and van der Waals contacts. As the size of portion-polymer nanoconjugate increased, the loading efficacy of DNA and RNA was increased (40% to 60%). Major alterations of DNA and RNA morphology occurred by nanoparticle interaction. Protein-polymer nanoconjugates are capable of delivering DNA and RNA to the target molecules.
Editora:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
Por (autor):
Heidar-Ali Tajmir-Riahi
Número de páginas:
72
Publicado em:
2019-09-10
Stock:
Disponível
Categoria:
Bioquímica, biofísica
Preço:
26.9 €
Palavras chave:
DNA, tRNA, Protein, Polymer, delivery, TEM

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