Capa do livro de Discovery of HIV-1 Integrase Inhibitors
Título do livro:

Discovery of HIV-1 Integrase Inhibitors

Furan and Sulfonamide-based Integrase Inhibitors

VDM Verlag Dr. Müller (2010-11-18 )

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ISBN- 1 3:

978-3-639-30281-3

ISBN- 1 0:
3639302818
EAN:
9783639302813
Idioma do livro:
Inglês
Anotações e citações/ texto breve:
Highly active antiretroviral therapy (HAART) is the current treatment regimen for HIV/AIDS, a disease that has claimed millions worldwide. HAART is a cocktail that inhibits different stages of the viral life cycle targeting protease, reverse transcriptase, and often includes anti-fusion inhibitor enfurvitide. The addition of HIV-1 integrase (IN) inhibitor raltegravir to HAART reveals a decrease of the virus to near undetectable levels in treatment-experienced patients. Although these successes are encouraging for antiviral therapy, specific mutations resistant to raltegravir have also appeared. Drug resistant mutations is the inevitable signature of HIV with a merry-go-round history of antiviral drug development and viral evolution, highlighting the need to identify new leads for IN inhibition. Absent of a cellular
Editora:
VDM Verlag Dr. Müller
Website:
http://www.vdm-verlag.de
Por (autor):
Tino Sanchez
Número de páginas:
60
Publicado em:
2010-11-18
Stock:
Disponível
Categoria:
Farmácia
Preço:
49 €
Palavras chave:
aids, HIV, inhibitors, Integrase, Drugs, Virus, Recombinant, pharmacology, Furan, dithiazines

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