Capa do livro de Development of Novel Peptide Inhibitors to BAG-1
Título do livro:

Development of Novel Peptide Inhibitors to BAG-1

Applications of Peptidyl-Biomimetics to reduce and eliminate tumor resistance to chemotherapy

LAP LAMBERT Academic Publishing (2014-02-26 )

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ISBN- 1 3:

978-3-8465-4302-3

ISBN- 1 0:
3846543020
EAN:
9783846543023
Idioma do livro:
Inglês
Anotações e citações/ texto breve:
One of the most challenging aspects of treating tumors with chemotherapy is that the tumors can develop a resistance to the chemotherapy and survive while the rest of the healthy, non-cancerous cells perish. Higher doses of chemotherapy deliver fewer positive results and at the expense of greater side effects. The purpose of this book it to identify and exploit a weakness at the molecular level of the anti-apoptotic pathway utilized by cancer cells to turn off the "triggered cell death" mechanism of apoptosis and survive chemotherapy. We specifically target the interaction between the anti-apoptotic protein Bcl-2 Associated Athanogene (BAG-1) and the 70-kilodalton Heat Shock Protein (HSP-70) that is suspected of driving the chemotherapeutic resistance, and seek to disrupt that interaction via peptidyl-biomimetically engineered peptides that are predicted via an in-house computational software named 'Contact" and experimentally verified via Biacore (c) binding assays.
Editora:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
Por (autor):
Jonathan Brunn
Número de páginas:
92
Publicado em:
2014-02-26
Stock:
Disponível
Categoria:
Bioquímica, biofísica
Preço:
54.9 €
Palavras chave:
Peptidyl-Biomimetics, apoptosis peptide t, therapeutic inhibitor antiapoptosis, mechanism of apoptosis, Tumors, Chemotherapy, Cancer

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