Role of Mast Cells in the Acute Phase Response
Behavioral and Cellular Analyses
978-3-639-08227-2
3639082273
120
2008-09-16
49,00 €
eng
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Pharmacological and transgenic methods were used to
investigate the roles of mast cells in the initial
response of the innate immune system to pathogens,
or acute phase response (APR). In rats, peripheral
and central cromolyn sodium, an inhibitor of mast
cell function, each reduced LPS-induced anorexia,
adipsia, inactivity and fever. LPS-induced
increases in plasma TNF-alpha concentrations were
also reduced by cromolyn. These data indicate that
peripheral and brain mast cells are involved in the
APR and, because peripheral and central cromolyn
produced different changes in many measures, that
the two populations of mast cells do not play
identical roles. In transgenic W/Wv mice lacking
functional mast cells, LPS produced anorexia and
adipsia, but not fever or inactivity. Fever and TNF-
alpha concentrations were normalized in W/Wv mice
that were reconstituted with bone marrow-derived
mast cells. These data indicate that mast cells play
a necessary biological role in the APR, perhaps
through the rapid release of TNF-alpha. These data
are relevant to basic researchers and clinicians
interested in the neuroendocrine response to
illness.
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