Copertina di Development of Novel Peptide Inhibitors to BAG-1
Titolo del libro:

Development of Novel Peptide Inhibitors to BAG-1

Applications of Peptidyl-Biomimetics to reduce and eliminate tumor resistance to chemotherapy

LAP LAMBERT Academic Publishing (14.10.2014 )

Books loader

Omni badge eleggibile a buono
ISBN-13:

978-3-659-61692-1

ISBN-10:
3659616923
EAN:
9783659616921
Lingua del libro:
Inglese
Risvolto di copertina:
One of the most challenging aspects of treating tumors with chemotherapy is that the tumors can develop a resistance to the chemotherapy and survive while the rest of the healthy, non-cancerous cells perish. Higher doses of chemotherapy deliver fewer positive results and at the expense of greater side effects. The purpose of this book is to identify and exploit a weakness at the molecular level of the anti-apoptotic pathway utilized by cancer cells to turn off the "triggered cell death" mechanism of apoptosis and survive chemotherapy. We specifically target the interaction between the anti-apoptotic protein Bcl-2 Associated Athanogene (BAG-1) and the 70-kilodalton Heat Shock Protein (HSP-70) that is suspected of driving the chemotherapeutic resistance, and seek to disrupt that interaction via peptidyl-biomimetically engineered peptides that are predicted via an in-house computational software named "Contact" and experimentally verified via Biacore (c) binding assays. The program "Contact" is now available for free download at http://www.engineering.vcu.edu/proteinengineering/
Casa editrice:
LAP LAMBERT Academic Publishing
Sito Web:
https://www.lap-publishing.com/
Da (autore):
Jonathan Brunn
Numero di pagine:
92
Pubblicato il:
14.10.2014
Giacenza di magazzino:
Disponibile
categoria:
Biochimica, Biofisica
Prezzo:
54,90 €
Parole chiave:
BAG-1 HSP-70 peptide inhibitor cancer tumor suppression peptidyl-biomimetics

Books loader

Newsletter

Adyen::amex Adyen::mc Adyen::visa Adyen::cup Adyen::unionpay Paypal Trasferimento

  0 prodotti nel carro d'acquisti
Modificare il carrello
Loading frontend
LOADING