Borítókép a Evaluation and Optimisation - hoz
Könyv címe:

Evaluation and Optimisation

of in silico designed HIV Reverse Transcriptase Modulators

LAP LAMBERT Academic Publishing (08.04.2019 )

Books loader

Omni badge Érvényes utalvány
ISBN-13:

978-3-659-95767-3

ISBN-10:
3659957674
EAN:
9783659957673
Könyv nyelve:
angol
Ismertető:
The Human Immunodeficiency Virus (HIV), has led to the emergence of Acquired Immunodeficiency Syndrome. The Reverse Transcriptase (RT) enzyme, which is involved in viral replication, was used as a target, to design novel molecules, mainly Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs). NNRTIs bind away from the catalytic site of RT and exert a conformational change to the structure of the enzyme inhibiting its conversion from viral RNA to DNA. Protein Data Bank crystallographic depositions describing the bound co-ordinates of different NNRTIs bound to the RT enzyme, namely 3HVT, 2ZD1, 4NCG, 3DRP and 3DOL, were modelled in SYBYL®X-1.2. The apo form of the enzyme was obtained and the Ligand Binding Pocket was mapped. Phase 1 of the study consisted of modifying lead molecules to create seeds differing in magnitude and growing site loci. These in turn were planted in the RT key-site using the GROW module of LigBuilder® V2. Molecular growth was carried out according to the pre-established growing sites and novel structures with different pharmacophores were generated.
Kiadó:
LAP LAMBERT Academic Publishing
Weboldal:
https://www.lap-publishing.com/
Szerezte:
Marie Mifsud
Oldalszám:
440
Kiadja:
08.04.2019
Raktárkészlet:
Raktáron
Kategória:
Egyéb
Ár:
98,90 €
Kulcsszavak:
evaluation, Optimisation, Management, Option

Books loader

Hírlevél

Adyen::amex Adyen::mc Adyen::visa Adyen::cup Adyen::unionpay Paypal Banki átutalás

  0 termékek a bevásárlókosárban
Kosár szerkesztése
Loading frontend
LOADING