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Könyv címe:

Development of Novel Peptide Inhibitors to BAG-1

Applications of Peptidyl-Biomimetics to reduce and eliminate tumor resistance to chemotherapy

LAP LAMBERT Academic Publishing (26.02.2014 )

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ISBN-13:

978-3-8465-4302-3

ISBN-10:
3846543020
EAN:
9783846543023
Könyv nyelve:
angol
Ismertető:
One of the most challenging aspects of treating tumors with chemotherapy is that the tumors can develop a resistance to the chemotherapy and survive while the rest of the healthy, non-cancerous cells perish. Higher doses of chemotherapy deliver fewer positive results and at the expense of greater side effects. The purpose of this book it to identify and exploit a weakness at the molecular level of the anti-apoptotic pathway utilized by cancer cells to turn off the "triggered cell death" mechanism of apoptosis and survive chemotherapy. We specifically target the interaction between the anti-apoptotic protein Bcl-2 Associated Athanogene (BAG-1) and the 70-kilodalton Heat Shock Protein (HSP-70) that is suspected of driving the chemotherapeutic resistance, and seek to disrupt that interaction via peptidyl-biomimetically engineered peptides that are predicted via an in-house computational software named 'Contact" and experimentally verified via Biacore (c) binding assays.
Kiadó:
LAP LAMBERT Academic Publishing
Weboldal:
https://www.lap-publishing.com/
Szerezte:
Jonathan Brunn
Oldalszám:
92
Kiadja:
26.02.2014
Raktárkészlet:
Raktáron
Kategória:
Biokémia, biofizika
Ár:
54,90 €
Kulcsszavak:
Peptidyl-Biomimetics, apoptosis peptide t, therapeutic inhibitor antiapoptosis, mechanism of apoptosis, Tumors, Chemotherapy, Cancer

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