Bookcover of Syntheses & Applications of Steroid-Amino Acid Conjugates & Complexes
Booktitle:

Syntheses & Applications of Steroid-Amino Acid Conjugates & Complexes

New 11β-AminoSteroid Conjugates & Complexes: From Syntheses to Applications as 11β-HSD2 inhibitors & Metallosurfactants

LAP LAMBERT Academic Publishing (2019-05-15 )

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ISBN-13:

978-613-9-84535-4

ISBN-10:
6139845351
EAN:
9786139845354
Book language:
English
Blurb/Shorttext:
Sesquiterpenoid- and steroid-amino acid conjugates demonstrate a broad array of interesting biological properties, as the different segments of the conjugate function collectively to regulate conformation, recognition, transport and solubility. The current project involved developing a facile methodology to synthesize metabolically stable facially amphiphilic conjugates by appending either amino acids (chapter 2) or cationic metal ligand-amino acid complexes (chapter 3) as hydrophilic segments on steroid progesterone and sesquiterpene amorpha-4,11-diene scaffolds. Aminosteroids and C-11 substituted steroids have attracted long lasting interest due to their diverse pharmacological properties. As the stereoselective C- 11β functionalization of a steroid imposes severe steric hindrance due to the C-18 and C-19 angular methyl groups, access to 11β-aminoprogesterone is a challenge. Chapter 2 describes stereoselective syntheses of a new family of aminosteroids: 11β-aminoprogesterone (11 -NH2-Pro) (76) and its derivatives, including its glycine 77 and L-/D- alanine- 78/79 based conjugates, by nucleophilic substitution or reductive amination.
Publishing house:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
By (author) :
Keyur Pandya
Number of pages:
280
Published on:
2019-05-15
Stock:
Available
Category:
Chemistry
Price:
82.90 €
Keywords:
Novel Amino Steroids, Amorphadiene-Amino Acids, metal complexes, surfactants, Amphiphilic Conjugates, Stereo-Selective Synthesis, 11β-steroids, Aminoprogesterone, Amorpha-4, 11-Diene, 11β-Hydroxysteroid Dehydrogenase Type 2, 11β-HSD2, antagonist, Mineralocorticoid Receptor (MR), 11β-Hydroxyprogesterone, Sesquiterpenoid, Ligand amino acid complexes, Modulators of Corticosteroid, Treating Electrolyte Disturbances, Inflammatory Disorders, Tethered Cationic Cobalt(III) based Biometallosurfactant Complexes

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