Bookcover of SUMOylation regulates RNA polymerase-III dependent transcription
Booktitle:

SUMOylation regulates RNA polymerase-III dependent transcription

Scholars' Press (2013-07-07 )

Books loader

Omni badge eligible for voucher
ISBN-13:

978-3-639-51488-9

ISBN-10:
3639514882
EAN:
9783639514889
Book language:
English
Blurb/Shorttext:
Elevated RNA polymerase III-dependent gene transcription is a hallmark of transformation and tumorigenesis. Understanding the mechanisms by which this process is regulated is key to understanding what goes wrong in cancer. Maf1 was identified as a novel transcriptional repressor that can repress transcription from all three mammalian RNA polymerases. In this study we demonstarted that SUMOylation of Maf1 is important for Maf1's ability to repress RNA polymerase III-dependent transcription. Additionally, SENP1 regulates SUMO modification of Maf1 which is important for Maf1's association with RNA polymerase III. Given that SENP1, Maf1 and RNA polymerase III-dependent transcrtipion play an important role in oncogenesis, our study supports the idea that deSUMOylation of Maf1 and induction of its target genes is important for cancer development.
Publishing house:
Scholars' Press
Website:
http://www.scholars-press.com
By (author) :
Aarti Rohira
Number of pages:
76
Published on:
2013-07-07
Stock:
Available
Category:
Biochemistry, biophysics
Price:
45.90 €
Keywords:
transcriptional regulation, RNA Polymerase III, SUMOylation, Maf1

Books loader

Newsletter

Adyen::amex Adyen::mc Adyen::visa Adyen::cup Adyen::unionpay Paypal Wire Transfer

  0 products in the shopping cart
Edit cart
Loading frontend
LOADING