Bookcover of Solid Self Micron Emulsifying Drug Delivery System of Rosuvastatin
Booktitle:

Solid Self Micron Emulsifying Drug Delivery System of Rosuvastatin

Noval Drug Delivery System (SSMEDDS) - Rosuvastatin Calcium

LAP LAMBERT Academic Publishing (2020-04-30 )

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ISBN-13:

978-613-9-91208-7

ISBN-10:
6139912083
EAN:
9786139912087
Book language:
English
Blurb/Shorttext:
The objective of present research work was to develop a self-emulsifying drug delivery system of Rosuvastatin Calcium (RC) for increasing its solubility, and oral bioavailability. Solubility of RC was determined in various vehicles. Oil, Surfactant and Cosurfactant were selected based on the solubility and HLB (Hydrophilic lipophilic balance) value. To identify the microemulsion existing zone Pseudo-ternary phase diagrams were constructed. Solubility analysis was also done for optimization of formulation. The optimised microemulsion formulation was evaluated for Powder X-Ray Diffraction (XRD), SEM (Scanning electron microscopy) analysis, globule size, zeta potential and phase separation study. Average globule size and zeta potential of the optimized microemulsion formulation were found to be 30 nm, and -11.5 mV, respectively. The viscosity and conductivity data indicated that the microemulsion was of the o/w type.The solubility of RC was successfully enhanced up to 82.32%. Percent drug release at the end of 60 min was found to be 76.74 %. The solubility of Rosuvastatin Calcium was significantly enhanced after formulating into self-emulsify microemulsion.
Publishing house:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
By (author) :
Amit Vishwakarma
Number of pages:
92
Published on:
2020-04-30
Stock:
Available
Category:
Pharmacy
Price:
54.90 €
Keywords:
Rosuvastatin Calcium, Self Micron Emulsifying Drug Delivery System, Drug Delivery System

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