Bookcover of Self Microemulsifying Drug Delivery System For Some Drugs
Booktitle:

Self Microemulsifying Drug Delivery System For Some Drugs

Development And Evaluation Of Self Microemulsifying Drug Delivery System For High Molecular Weight Drugs

LAP LAMBERT Academic Publishing (2014-09-05 )

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ISBN-13:

978-3-659-59514-1

ISBN-10:
3659595144
EAN:
9783659595141
Book language:
English
Blurb/Shorttext:
BCS class II are poorly water soluble and some drugs have high molecular weight, more than eleven hydrogen bond acceptors, more than five hydrogen bond doner. Thus, it exhibits poor bioavailability. A new Solid-Self Emulsifying Drug Delivery System (S-SMEDDS) of Drugs has been successfully developed to enhance its oral bioavailability by improving its solubility and facilitating high molecular weight of Drugs absorption. The primary composition of SMEDDS formulation was selected from solubility, pseudoternary phase diagram, emulsifying efficiency and compatibility test for preparation of (L-SMEDDS). Drug loaded L-SMEDDS were prepared in different concentration of oil, surfactant/co-surfactant and optimized by various evolutionary parameter such as robustness to dilution, drug content, ultrasonic interferometer, ease of emulsification, droplet size and in vitro diffusion study. The optimized L-SMEDDS converted into free flowing granules by spray drying technique. S-SMEDDS powder undergoes for characterization and confirmed the no interaction between drug and excipients.Thus, the present investigation improved the oral bioavailability of Drugs.
Publishing house:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
By (author) :
Vikrant Wankhade
Number of pages:
280
Published on:
2014-09-05
Stock:
Available
Category:
Pharmacy
Price:
82.90 €
Keywords:
SMEDDS, In-vivo study, Biovailability, pharmacokinetic parameters, ultrasonic resonance technology, Spray drier technology, Microemulsion

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