Bookcover of Oxidative Stress and Wound Healing in Type 2 Diabetics with Foot Ulcer
Booktitle:

Oxidative Stress and Wound Healing in Type 2 Diabetics with Foot Ulcer

Oxidative Stress in Diabetic Foot Ulcer Patients

LAP LAMBERT Academic Publishing (2014-05-21 )

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ISBN-13:

978-3-8383-2809-6

ISBN-10:
3838328094
EAN:
9783838328096
Book language:
English
Blurb/Shorttext:
Lower-limb infections are major causes of morbidity and mortality in diabetic patients. Oxidative stress (OS) has been implicated in the pathogenesis of diabetes mellitus and its complications including diabetic foot ulcer. Persistent hyperglycaemia leads to an increased production of reactive oxygen species (ROS) through glucose auto-oxidation, sorbitol pathway and protein glycation. This study investigated the effects of selenium, Vitamins C & E supplementations on OS indices: 4-hydoxy-2′-nonenal (4-HNE), lipid peroxides (LPO) and 8–hydroxy–2΄–deoxyguanosine (8–OHdG) as well as antioxidant defence system: Superoxide dismutase (SOD), glutathione peroxidase (GPx) and total antioxidant status (TAS)on wound healing in diabetic ulcers in both experimental and clinical models. Data before supplementation revealed higher levels of 4-HNE, LPO and 8-OHdG in diabetic groups with or without ulcer compared with the non-diabetic groups. The diabetic ulcer groups exhibited greater increase in levels of OS indices. Antioxidant supplementation was observed to reduce OS indices and improve healing in both experimental and clinical diabetics with and without ulcers.
Publishing house:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
By (author) :
Elizabeth Bolajoko, Kensese Mossanda
Number of pages:
244
Published on:
2014-05-21
Stock:
Available
Category:
Other
Price:
69.90 €
Keywords:
oxidative stress, diabetic mellitus, diabetic foot and wound healing

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