Bookcover of Multicomponent One Pot Green Synthesis of 1, 5-Benzodiazepines
Booktitle:

Multicomponent One Pot Green Synthesis of 1, 5-Benzodiazepines

Investigating various acids for its catalytic potential and their mechanism

LAP LAMBERT Academic Publishing (2012-12-07 )

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ISBN-13:

978-3-8454-2258-9

ISBN-10:
3845422580
EAN:
9783845422589
Book language:
English
Blurb/Shorttext:
Multicomponent Reactions (MCRs) are a promising and vital field of green chemistry. Benzodiazepines are widely used class of bioactive compounds due to their remarkable biological and pharmacological properties. However, many of the methods of synthesis of benzodiazepines suffer major or minor limitations like tedious work up procedure, applications of expensive and hazardous catalyst, long reaction times, unsatisfactory yields, require separation of the catalyst from the product and formation of side products. In our project, we have reviewed the various heterogenous and homogenous catalysts utilized for the synthesis of 1, 5-benzodizepines in the last decade and explored the novel, non-expensive, easily available, non toxic catalyst for the efficient synthesis of 1,5-benzodiazepines under solvent-free conditions. The catalytic efficiency of various acids studied, are categorized in four categories with their proposed mechanism of actions: Amino acids, Aliphatic acids, Aromatic acids and Miscellaneous acids. The remarkable features of these new acid catalysts are high yield, short reaction times, cleaner reaction profiles and high regioselectivity.
Publishing house:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
By (author) :
Akshdeep Sandhar
Edited by:
Rajesh K. Singh
Number of pages:
136
Published on:
2012-12-07
Stock:
Available
Category:
Pharmacy
Price:
59.00 €
Keywords:
1, mechanism, Green Chemistry, acids, catalytic properties, Multicomponent reaction, solvent-free, 5-benzodiazepines

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