Bookcover of Microfluidics
Booktitle:

Microfluidics

An Application of Physics in Medicine

LAP LAMBERT Academic Publishing (2019-09-06 )

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ISBN-13:

978-620-0-29938-3

ISBN-10:
6200299382
EAN:
9786200299383
Book language:
English
Blurb/Shorttext:
The mechanical properties of cells are often an indicator of disease. Red blood cells (RBCs) are easily deformable, thus its viability depends greatly on its extracellular medium. In this book, a microfluidic channel with the top wall decorated by a periodic array of rigid diagonal ridges that can sort RBCs with different stiffness is presented. It can give rise to a stiffness-dependent force, thus induce transverse separation. RBCs with extracellular media of 0.89% and 0.59% sodium chloride concentrations are separated. By bathing RBCs to various salt concentrations, its shape morphology and also its viscoelastic properties change. The total RBC count also correlated with the %salinity concentrations. These findings support observations relating salinity in blood with RBC count in physiological conditions. With a flow rate of 0.02mL/min and cell concentration of 3.2 x 1010cells/mL, the outlets of the microfluidic device were able to collect RBCs with a total retention of 78%. The analysis should help shed light to the role of physics in medicine. Microfluidics can be an approach to a powerful clinical tool for blood analysis and supplementary tool for disease detection method.
Publishing house:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
By (author) :
Clare Maristela V. Galon, Rommel G. Bacabac
Number of pages:
60
Published on:
2019-09-06
Stock:
Available
Category:
Biochemistry, biophysics
Price:
32.90 €
Keywords:
Microfluidics, Red blood cells, cell sorting, Microrheology, blood, osmosis, machine vision, viscoelasticity, video microscopy, Salinity

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