Bookcover of Lysosomes and Tay- Sachs disease
Booktitle:

Lysosomes and Tay- Sachs disease

Tay- Sachs disease

Scholars' Press (2019-10-10 )

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ISBN-13:

978-613-8-91279-8

ISBN-10:
6138912799
EAN:
9786138912798
Book language:
English
Blurb/Shorttext:
Lysosomes and their equivalent structures (known as vacuoles in yeast and plant cells) have long been established as the degradative end points for both intracellular and exogenous cargo. The catabolic function of the lysosome is accomplished by an array of approximately 60 proteases, lipases, nucleases and other hydrolytic enzymes that break down complex macromolecules into their constituent building blocks Tay–Sachs disease is a genetic disorder that results in the destruction of nerve cells in the brain and spinal cord. It is inherited from a person's parents in an autosomal recessive manner. The mutation results in problems with an enzyme called beta-hexosaminidase A which results in the build-up of the molecule GM2 ganglioside within cells, leading to toxicity. The development of enzyme replacement therapy (ERT) is apromising option for the treatment of lysosomal storage diseases.
Publishing house:
Scholars' Press
Website:
http://www.scholars-press.com
By (author) :
Eman Youness, Hesham Orban, Eman Youness
Number of pages:
68
Published on:
2019-10-10
Stock:
Available
Category:
Zoology
Price:
45.90 €
Keywords:
tay-sac, lysosome

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