Bookcover of Immunofluoresecence Based Study on Breast Cancer Patients
Booktitle:

Immunofluoresecence Based Study on Breast Cancer Patients

FlowCytometric Study on Surface Antigen Markers (CD3, CD4 and CD8) and DNA Content Analysis in Breast Cancer Carcinoma

LAP LAMBERT Academic Publishing (2010-09-14 )

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ISBN-13:

978-3-8383-9762-7

ISBN-10:
3838397622
EAN:
9783838397627
Book language:
English
Blurb/Shorttext:
Cancer is high proliferation of cells due to abnormalities in cell division and DNA replication. Breast cancer is most common malignancy of women with 45-80% response rate. However, recurrence is most common and most of the patients do not develop a satisfactory immunological antitumour response due to several mechanism, T-cells dysfunction. It is about 1% in men. In present study, we tried to investigate the role of T-cells and DNA content analysis as prognostic marker in breast cancer patients compared to normal healthy individuals using Flowctometry and Confocal Laser Scanning Microcopy. We studied 31 Breast carcinoma patients and 12 Normal healthy persons. Out of 31 patients, cancer patients showed significant increase in CD3, CD4 percentage while there was no significant change in CD8 percentage. Increased CD4 values suggested that these cells have immunosuppressive characterstics either due to cell contact or soluble factors and therefore contribute to dysfunction of immune system against cancer cells. Flowcytometry can assist pathologist in making objective, quantitative measurements on cells and tissue which can compliment pathological diagnosis.
Publishing house:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
By (author) :
Saurabh Varma, Rishikesh Shukla
Number of pages:
112
Published on:
2010-09-14
Stock:
Available
Category:
Clinical disciplines
Price:
49.00 €
Keywords:
Breast Cancer, Flow Cytometry, Confocal Laser Scanning Microscopy, Immunological Responses, DNA ploidy

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