Bookcover of Hepatitis C virus antigen cellular response to HLA class 1 allele
Booktitle:

Hepatitis C virus antigen cellular response to HLA class 1 allele

Hepatitis C virus (HCV) antigen specific cellular response in patients with HCV with various HLA Class I alleles

LAP LAMBERT Academic Publishing (2011-12-27 )

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ISBN-13:

978-3-8473-3060-8

ISBN-10:
3847330608
EAN:
9783847330608
Book language:
English
Blurb/Shorttext:
Clinical and virological outcomes are variable following acute infection with HCV. Chronic infection is characterized by attenuated and narrowly focused CD4+ and CD8+ T-cell responses in conjunction with reduced proliferative, cytokine, and cytolytic capacity of HCV-specific T cells and loss of antigen recognition. Conversely, CD4 and CD8 T-cell responses are maintained in individuals who clear the virus. Therefore, effective T-cell-dependent immune responses to HCV-specific viral epitopes, restricted by the presence of host human leukocyte antigens (HLA) class I (CD8 cytotoxic T cells [CTL]) and class II (CD4 helper T cells), appear to make an important contribution to adaptive immunity and disease outcome.
Publishing house:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
By (author) :
Chinmaya Mahapatra
Number of pages:
80
Published on:
2011-12-27
Stock:
Available
Category:
Clinical disciplines
Price:
49.00 €
Keywords:
MHC-1, T-cells, virology, Hepatitis C

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