Bookcover of Gene Delivery by Protein-Polymer Nanoconjugates
Booktitle:

Gene Delivery by Protein-Polymer Nanoconjugates

LAP LAMBERT Academic Publishing (2019-09-10 )

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ISBN-13:

978-620-0-23222-9

ISBN-10:
6200232229
EAN:
9786200232229
Book language:
English
Blurb/Shorttext:
In this book, we explore the potential applications of protein-polymer nanoconjugates in gene delivery. Conjugation of human serum albumin (HSA), bovine serum albumin (BSA) and beta-lactoglobulin (β-LG) with chitosan (carbohydrates) and PAMAM (dendrimers) of different sizes were used to transport DNA and RNA. Thermodynamic analysis showed that the conjugation of DNA and RNA to protein-polymer nanoparticles occurred via hydrophilic, hydrophobic, H-bonding and van der Waals contacts. As the size of portion-polymer nanoconjugate increased, the loading efficacy of DNA and RNA was increased (40% to 60%). Major alterations of DNA and RNA morphology occurred by nanoparticle interaction. Protein-polymer nanoconjugates are capable of delivering DNA and RNA to the target molecules.
Publishing house:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
By (author) :
Heidar-Ali Tajmir-Riahi
Number of pages:
72
Published on:
2019-09-10
Stock:
Available
Category:
Biochemistry, biophysics
Price:
26.90 €
Keywords:
DNA, tRNA, Protein, Polymer, delivery, TEM

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