Bookcover of Formulation and process variables influencing nanoparticles properties
Booktitle:

Formulation and process variables influencing nanoparticles properties

Factors influencing properties of nanoparticles prepared by nanoprecipitation and emulsification-based methods

LAP LAMBERT Academic Publishing (2017-12-20 )

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ISBN-13:

978-620-2-07766-8

ISBN-10:
6202077662
EAN:
9786202077668
Book language:
English
Blurb/Shorttext:
Having in mind the toxicity of certain drugs, problems associated with multi drug resistance and favorable pharmacokinetic properties offered by nanoparticulated drug delivery systems (NDDS), it could be said that nanoencapsulation is a challengeable and interesting approach to achieve desired benefits of lower toxicity and increased drug accumulation into the target tissue/organ. The first step that needs to be mastered in the NDDS design, is to achieve prolonged blood circulation time by providing the adequate nanoparticle (NP) size (<200 nm), surface charge (preferably neutral), shape and surface properties (preferably hydrophilic) as basic requirements for circumvention of mononuclear phagocyte system and desired NDDS accumulation into the targeted tissue. So, when optimizing NP formulations in order to achieve the desired characteristics in vivo, it is of high importance to consider the various preparation, formulation and process factors that can influence the NP size, zeta potential, encapsulation efficiency and drug dissolution, among other properties. This review gives an overview of most studied factors influencing NDDS physicochemical and biopharmaceutical properties.
Publishing house:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
By (author) :
Maja Simonoska Crcarevska, Marija Glavas Dodov, Nikola Lazarevski
Number of pages:
120
Published on:
2017-12-20
Stock:
Available
Category:
Pharmacy
Price:
49.90 €
Keywords:
encapsulation efficiency, Nanoparticles, Particle Size, physicochemical properties, Zeta Potential, biopharmaceutical properties, factors of influence, Drug Release

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