Bookcover of Enhancement of complexation of drug: binary and ternary mixtures
Booktitle:

Enhancement of complexation of drug: binary and ternary mixtures

Bhati et al. enhancement of complexation

LAP LAMBERT Academic Publishing (2012-04-08 )

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ISBN-13:

978-3-8484-9390-6

ISBN-10:
384849390X
EAN:
9783848493906
Book language:
English
Blurb/Shorttext:
The study demonstrated the possibility of significantly improving the dissolution performance of MX by simultaneous complexation with cyclodextrin. The importance of proper selection of the most suitable counter ion to adequately improve the cyclodextrin - complexation efficiency has been pointed out. PVP showed a synergistic effect when used in combination with HPβ-CD. Phase solubility experiments demonstrated that the ternary system with PVP (pH 5.8) exhibited a stability constant 12.9 times greater than the binary complex. The drug solubility in the presence of 50mM HPβ-CD was about 6.23 times higher than that in the binary system. Results confirmed that the strong increase in the drug solubility shown by HPβ-CD ternary system with PVP. Solid state demonstrated that freeze drying technique was suitable for obtaining solid homogeneous equimolar MX-HPβ-CD-PVP complexes. These systems could be useful for formulating fast-dissolving drug solid dosage form able to assure rapid onset of analgesic action and improved bioavailability.
Publishing house:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
By (author) :
Lokesh Kumar Bhati, Meena Bhati, Gaurav Tiwari
Number of pages:
120
Published on:
2012-04-08
Stock:
Available
Category:
Other
Price:
49.00 €
Keywords:
Meloxicam, β cyclodextrin, Hydroxy Propyl β cyclodextrin, PVP K30, binary and ternary systems.

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