Bookcover of Cigarette smoking & DNA-damage
Booktitle:

Cigarette smoking & DNA-damage

Comparison of severity of DNA-damage in gastric tissue, levels of Nitric Oxide and oxidative stress in gastric juice of

LAP LAMBERT Academic Publishing (2011-11-29 )

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ISBN-13:

978-3-8465-9786-6

ISBN-10:
3846597864
EAN:
9783846597866
Book language:
English
Blurb/Shorttext:
Cigarette smoking is associated with an increase in risk of peptic ulcer and Gastro-Intestinal cancer. Oxidative and nitrosative stress accompanied by toxic materials in smoke and tar has a significant role in production of carcinogenic complexes and injury to DNA and cellular proliferation in gastric cancer. The study designed to compare the rate of injuri to DNA in gastric tissue, the levels of nitric oxide (NO0) and severity of oxidative stress in gastric juice of smoker and non-smoker patients with active peptic ulcer. Results of this study approve the direct relation between increase in DNA damage and toxic complexes existing in smoke and tar of cigarette, especially NOo radicals. It seems that reactive spaices of oxygen and nitrogene such as peroxide, peroxinitrit and new unknown complexes that forms mediating the reaction between tar and nitric oxide, have an important role in DNA damage and diseases related to tobacco products such as gastric cancer and results of this study based upon increase in superoxide dysmutase and gluthation peroxidase activities and reduction in total anti-oxidant capacity in gastric juice indicates the increase in oxidative stress in smoker's gas.
Publishing house:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
By (author) :
Mohammad-Hosein Somi, Ebrahim Fattahi, Homayun Dolatkhah
Number of pages:
64
Published on:
2011-11-29
Stock:
Available
Category:
Medicine
Price:
49.00 €
Keywords:
cigarette smoking, Oxidative and Nitrosative Stress, Active Peptic Ulcer, DNA damage, nitric oxide

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