Bookcover of Cellular Responses to AIDS-Virus Infection
Booktitle:

Cellular Responses to AIDS-Virus Infection

Understanding the Antiviral Efficacy and Breadth of CD8+ T Lymphocytes against Simian Immunodeficiency Virus

VDM Verlag Dr. MŸller Aktiengesellschaft & Co. KG (2008-04-28 )

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ISBN-13:

978-3-8364-9286-7

ISBN-10:
3836492865
EAN:
9783836492867
Book language:
English
Blurb/Shorttext:
In 2007, approximately 33 million people were living with HIV/AIDS worldwide, while an estimated 2.5 million new infections occurred and 2.1 million AIDS-related deaths. With >95% of new infections occurring in low and middle income countries with limited access to antiretroviral therapy, the development of a prophylactic HIV vaccine remains one of the world's top public health priorities. Many studies illustrate the important role of CD8+ T lymphocytes, also known as cytotoxic T lymphocytes (CTL), in controlling HIV and simian immunodeficiency virus (SIV) replication. However, the correlates of immune protection remain unknown. The SIV-infected rhesus macaque is the most widely used animal model for studying HIV infection. We enhanced the utility of this model by evaluating the breadth of novel, SIV-specific CTL responses in infected macaques. We then examined the antiviral efficacy of these SIV-specific CTL using a novel viral suppression assay. This information may be important in determining the type of CTL epitopes to be targeted in future HIV vaccines. This research should be especially useful for those studying cellular immune responses against AIDS-virus infection.
Publishing house:
VDM Verlag Dr. MŸller Aktiengesellschaft & Co. KG
By (author) :
John Loffredo
Number of pages:
264
Published on:
2008-04-28
Stock:
Available
Category:
Microbiology
Price:
79.00 €
Keywords:
Human Immunodeficiency Virus (HIV), simian immunodeficiency virus (SIV), acquired immune deficiency syndrome (AIDS), immunology, Vaccine, CD8+ T cells/cytotoxic T lymphocytes (CTL), major histocompatibility complex (MHC), CD8+ T cell immunodominance, CD8+ T cell antiviral efficacy, viral escape

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