Bookcover of Cancer of Uterine Cervix and PTEN tumor suppressor gene
Booktitle:

Cancer of Uterine Cervix and PTEN tumor suppressor gene

Genetic and Epigenetic alterations in PTEN gene among Cervical Cancer patients

LAP LAMBERT Academic Publishing (2011-02-24 )

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ISBN-13:

978-3-8443-0287-5

ISBN-10:
3844302875
EAN:
9783844302875
Book language:
English
Blurb/Shorttext:
Cancer of uterine cervix is one of the most common malignant diseases affecting women worldwide. It is responsible for almost 20 percent of all female deaths in India with almost 130,000 new cases every year. Multiple alterations are necessary for the development of this cancer in addition to the HPV infection. Comparatively a younger tumor suppressor gene, PTEN, was found to be located on chromosome 10q23.3 with nine exons and is deleted and mutated in a variety of human cancers. PTEN is expressed in normal cervical epithelium, implying that loss of function may have some consequences in cervical cancer. We analyzed carcinoma cases for detection of PTEN promoter methylation, mutation, gene expression and apoptosis. Promoter methylation was detected in 61% cases and found to be correlated with the loss of PTEN expression, suggesting that silencing of PTEN gene definitely contribute in the tumorigenesis of cervical cancer. This work is expected to attract the attention of both the clinicians and researchers in the fields of oncology.
Publishing house:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
By (author) :
M Shabbir Alam, M Moshahid A Rizvi
Number of pages:
132
Published on:
2011-02-24
Stock:
Available
Category:
Clinical disciplines
Price:
59.00 €
Keywords:
Loss of Heterozygosity, Cervical carcinoma, Human Papilloma Virus, Tumor suppressor gene, PTEN, Squamous Cell Carcinoma, Immunohistochemistry, Promoter methylation, Adenocarcinoma, Apoptosis., HUMAN PAPILLOMA VIRUSES, Tumor Suppressor Gene, squamous cell carcinoma, immunohistochemistry, apoptosis

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