Bookcover of Cancer Informatics
Booktitle:

Cancer Informatics

Computational Analysis Of Significant Missense Mutations In Various Cancer Genes And Their Drug Targets

LAP LAMBERT Academic Publishing (2012-09-06 )

Books loader

Omni badge eligible for voucher
ISBN-13:

978-3-659-23425-5

ISBN-10:
3659234257
EAN:
9783659234255
Book language:
English
Blurb/Shorttext:
Cancer is a complex genetic disease as a result of accumulation of mutations. The study of these mutations not only reveals the molecular mechanism of tumoriogenesis but also provides insight for the development of novel therapeutics and diagnostic approaches. Missense mutations are among the most common types of mutations and can cause a various types of cancer. Deleterious effects of missense mutations are usually attributed to changes in the primary amino acid sequence, protein structure and function. Identifying the detrimental missense mutations in cancer genes and their drug targets are the challenging task in cancer biology. As missense variants are commonly identified in genomic sequence, only a small fraction directly contributed to oncogenesis. The ability to distinguish those missense changes that contribute to cancer progression and drug resistance from those that do not is a difficult problem usually accomplished through functional in vivo analysis. Hence, this book provides a computational protocol for identifying the detrimental missense mutation of various cancer genes in a lucid manner.
Publishing house:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
By (author) :
R. Rajasekaran, Rao Sethumadhavan, P. Chandrasekaran
Number of pages:
280
Published on:
2012-09-06
Stock:
Available
Category:
Biochemistry, biophysics
Price:
68.00 €
Keywords:
modeling, Genes, tumor, docking, suppressor, Oncogenes, Normal Mode Analysis, RMSD

Books loader

Newsletter

Adyen::amex Adyen::mc Adyen::visa Adyen::cup Adyen::unionpay Paypal Wire Transfer

  0 products in the shopping cart
Edit cart
Loading frontend
LOADING