Bookcover of Berberine - An alternative treatment for lung cancer
Booktitle:

Berberine - An alternative treatment for lung cancer

Effect of berberine on human lung carcinoma cell line (A549) and experimental lung cancer

LAP LAMBERT Academic Publishing (2010-12-01 )

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ISBN-13:

978-3-8383-9960-7

ISBN-10:
3838399609
EAN:
9783838399607
Book language:
English
Blurb/Shorttext:
In the present investigation, the efficacy of berberine in human lung carcinoma cell line (A549) and experimental lung cancer were studied. The viability of A549 cells was significantly reduced by berberine treatment, indicating that the treatment is cytotoxic. This was confirmed from the results that levels of marker enzymes and synthesis of nucleic acids were reduced on berberine treatment.Similarly the increased level of intra cellular calcium, p53 protein expression and cytochrome C paves the way for caspases activation; thereby induction of apoptosis and cell cycle arrest ensues that indicates the anti- proliferative potential and anticancer activity of berberine. Moreover, on berberine treatment, the lung cancer bearing animals have showed significant increase in body and organ weight. The lipid peroxidation and glycoproteins levels were decreased on treatment. Altered activities of membrane bound ATPase, Phase I biotransformation enzymes and the levels of ICDH, SDH, MDH and α – KGDH due to mitochondrial damage were noticeably reverted back to near normal in treated animals. Histopathological studies confirm the recovery from the neoplastic conditions.
Publishing house:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
By (author) :
Madhusudhanan , . Thiyagarajan, . Balasubramanian
Number of pages:
184
Published on:
2010-12-01
Stock:
Available
Category:
Clinical disciplines
Price:
68.00 €
Keywords:
"Lung cancer treatment" "Ayurvedic medicine" "Alternative medicine" "Indian medicines" "Cancer research" "Classical medicines"

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