Bookcover of Autoantibodies in Neurological Disorders
Booktitle:

Autoantibodies in Neurological Disorders

Neuronal and Muscle Autoantibodies in Paraneoplastic Neurological Disorders and Autoimmune Myasthenia Gravis

LAP LAMBERT Academic Publishing (2010-08-02 )

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ISBN-13:

978-3-8383-8220-3

ISBN-10:
383838220X
EAN:
9783838382203
Book language:
English
Blurb/Shorttext:
Paraneoplastic neurological disorders (PND) are due to immune-mediated damage of the nervous system, and the immune response is believed to be triggered as anti-tumor immunity. Early recognition of PND facilitates prompt detection of underlying tumors. Detection of paraneoplastic neuronal autoantibodies facilitates early diagnosis of PND. A novel paraneoplastic neuronal antibody, anti-neuronal nuclear antibody type 3 (ANNA-3) was identified in eleven patients, the majority had SCLC and diverse neurological manifestations. Autoimmune myasthenia gravis (MG) is due to impaired neuromuscular transmission predominantly due to pathogenic acetylcholine receptor (AChR) autoantibodies. Muscle-specific tyrosine kinase (MuSK) autoantibodies are detected in some AChR autoantibodies-negative generalized MG patients. Among 562 Mayo Clinic patients with adult- onset generalized MG based on clinical and electrophysiological criteria, AChR autoantibodies seronegativity rate was 8.2% and MuSK autoantibodies was detected in 38% of AChR autoantibodies-negative patients. The seronegativity rate in adult-onset generalized MG is ~5%.
Publishing house:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
By (author) :
Koon Ho CHAN
Number of pages:
256
Published on:
2010-08-02
Stock:
Available
Category:
Clinical disciplines
Price:
79.00 €
Keywords:
Autoantibodies, autoimmune neurological disorders, neuronal autoantibodies, muscle autoantibodies, paraneoplastic neurological disorders, autoimmune myasthenia gravis, anti-neuronal nuclear antibody type-3 (ANNA-3), acetylcholine receptor autoantibodies

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