Bookcover of Alosetron
Booktitle:

Alosetron

Alphascript Publishing (2010-12-07 )

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ISBN-13:

978-613-3-82637-3

ISBN-10:
6133826371
EAN:
9786133826373
Book language:
English
Blurb/Shorttext:
Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Alosetron Lotronex; originator is a 5-HT3 antagonist used for the management of severe diarrhea-predominant irritable bowel syndrome (IBS) in women only. It is currently marketed by Prometheus Laboratories Inc. (San Diego), also under the trade name Lotronex. Alosetron was withdrawn from the market in 2000 owing to the occurrence of serious life-threatening gastrointestinal adverse effects, but was reintroduced in 2002 with availability and use restricted; it was the first drug ever returned to the U.S. market after withdrawal for safety concerns. In 2001, the editor of the renowned medical journal The Lancet, Richard Horton, critizised the FDA's handling of alosetron in an unusually sharp language.Horton argued that the treatment of a non-fatal condition did not justify the use of a drug with potentially lethal side effects, and that the FDA should have revoked the approval for alosetron sooner when postmarketing surveillance revealed that many patients had suffered constipation necessitating surgical intervention and ischaemic colitis.
Publishing house:
Alphascript Publishing
Website:
https://www.alphascript-publishing.com/
Edited by:
Frederic P. Miller, Agnes F. Vandome, John McBrewster
Number of pages:
88
Published on:
2010-12-07
Stock:
Available
Category:
Medicine
Price:
34.00 €
Keywords:
Horton, lancet, Richard, Lotronex

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