Couverture de Pulsincap DDS for Chronotherapy
Titre du livre:

Pulsincap DDS for Chronotherapy

Development and evaluation of pulsincap DDS for chronotherapy

LAP LAMBERT Academic Publishing (24-06-2019 )

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ISBN-13:

978-620-0-09253-3

ISBN-10:
6200092532
EAN:
9786200092533
Langue du livre:
Anglais
texte du rabat:
The present work showed that pulsatile release of bambuterol HCL was successfully formulated by pulsincap drug delivery system. In formulating pulsatile drug delivery, the polymers used was hydrophilic polymer showing erodible behavior i.e. low viscosity grade HPMCK4M. for hydrogel plug. The sodium starch glycolate were used, which creates internal pressure on hydration and achieves the bursting effect. On the basis of 32 factorial design 9 batches were formulated, from F3, F6, F9 Contains 200 mg of HPMCK4M. in these formulations, the required lag time was not achieved i.e. 6 hour because of higher concentration of HPMCK4M. In case of F2, F5, F8 the concentration used were 175mg of HPMCK4M. these formulations showed the drug release from 4 hrs up to 9 hrs so these batches also were unable to show significant lag time.Now, in the F1, F4, F7 the concentration HPMCK4M used were 150 mg. in case of these batches the results obtainted were satisfactory and here the required lag time was also achieved, among these three batches f4 was selected as an optimized batch, as it showed the maximum release i.e. up to 61% in 6 hrs and rest of the drug was rest of the drug was released in 8 hr.
Maison d'édition:
LAP LAMBERT Academic Publishing
Site Web:
https://www.lap-publishing.com/
de (auteur) :
Monali Muneshwar, Minakshi Rathod
Numéro de pages:
84
Publié le:
24-06-2019
Stock:
Disponible
Catégorie:
Autres
Prix:
39.90 €
Mots-clés:
pulcincap, Capsules

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