Opioid Antagonist
978-613-5-45169-6
6135451693
148
2011-05-18
45.00 €
eng
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Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. An opioid antagonist is an receptor antagonist that acts on opioid receptors. Naloxone and naltrexone are commonly used opioid antagonist drugs which are competitive antagonists that bind to the opioid receptors with higher affinity than agonists but do not activate the receptors. This effectively blocks the receptor, preventing the body from responding to opiates and endorphins. Some opioid antagonists are not pure antagonists but in fact do produce some weak opioid partial agonist effects, and can produce analgesic effects when administered in high doses to opioid-naive individuals. Examples of such compounds include nalorphine and levallorphan. However the analgesic effects from these drugs are limited and tend to be accompanied by dysphoria, most likely due to action at the kappa opioid receptor.
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Pharmacie
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