Couverture de Lung Cancer
Titre du livre:

Lung Cancer

A Comparative Assessment of the Roles of RAS and EGFR Protein Families

LAP LAMBERT Academic Publishing (06-04-2012 )

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ISBN-13:

978-3-8484-9833-8

ISBN-10:
3848498332
EAN:
9783848498338
Langue du livre:
Anglais
texte du rabat:
Lung Cancer is a disease of uncontrolled cell growth and replication in lung tissues.These rapidly growing cells begin to invade adjacent tissues and thus lung cancer acts to be Metastatic in nature. This work aims to obtain a comparative and statistical collaboration of conserved mutated and unmutated patterns in lung cancer patients while highlighting RAS and EGFR Protein Families which are actively involved in the pathogenesis of Lung Cancer.A variety of bioinformatics tools and search engines were used to arrive at the sequence, structure and function of the proteins of these families. Inter protein analysis, Intra Protein analysis, conserved pattern identification, Mutation study, Protein-Protein interaction and Primer Designing were performed. On the basis of various parameters protein binding site was identified.Simulation was performed to get the optimized energy.The drug discovery program includes finding all chemical compounds having potential to inactive the protein.Virtual screening and docking studies were performed.The present study contributes to the possibility that genetic components are more important as compared to environmental and smoking(carcinogens) factors.
Maison d'édition:
LAP LAMBERT Academic Publishing
Site Web:
https://www.lap-publishing.com/
de (auteur) :
Anupam Bhattacharya, Pompi Sharma
Numéro de pages:
240
Publié le:
06-04-2012
Stock:
Disponible
Catégorie:
Biologie
Prix:
79.00 €
Mots-clés:
Bioinformatics, comparative analysis, Ras, lung cancer, EGFR, Protein analysis, In-silico Docking.

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