Couverture de FUNCTIONAL GENETIC VARIANTS AND MENTAL DISORDERS
Titre du livre:

FUNCTIONAL GENETIC VARIANTS AND MENTAL DISORDERS

Single nucleotide polymorphisms and their effects in genes involved in mental disorders

VDM Verlag Dr. Müller (26-06-2009 )

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ISBN-13:

978-3-639-16645-3

ISBN-10:
3639166450
EAN:
9783639166453
Langue du livre:
Anglais
texte du rabat:
Mental disorders are complex diseases with strong genetic components. Clinical studies have demonstrated the associations of genetic variants in candidate genes with susceptibility to several common mental diseases such as schizophrenia, depression, bipolar disorders, and drug addiction, but little was known about the underlying mechanisms. Single nucleotide polymorphisms (SNPs), naturally occurring nucleotide substitutions in DNA sequence, are the most common genetic variants, which can modulate gene expression at the level of mRNA and protein by affecting transcription, mRNA processing, pre-mature RNA splicing, mRNA stability, or translation. My studies examined the extent and nature of SNPs in mu opioid receptor and D2 dopamine receptor genes, which provided a foundation for clinical association studies by clarifying the functional relevance of these SNPs with susceptibility to mental disorders. My work should be especially useful to professionals in neuroscience, psychiatry, and genetics or anybody who are interested in understanding the genetic mechanisms of mental disorders.
Maison d'édition:
VDM Verlag Dr. Müller
Site Web:
http://www.vdm-verlag.de
de (auteur) :
Ying Zhang
Numéro de pages:
140
Publié le:
26-06-2009
Stock:
Disponible
Catégorie:
Génétique
Prix:
59.00 €
Mots-clés:
mental disorders, genetic variants, Mu opioid receptor, Dopamine D2 receptor, gene expression, alternative splicing, Drug addiction, allele-specific expression, polymorphisms, working memory, gene expression

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