Couverture de Floating Strategie & Low Absorption Drug
Titre du livre:

Floating Strategie & Low Absorption Drug

Needs of Floating Drug Delivery System

LAP LAMBERT Academic Publishing (05-05-2012 )

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ISBN-13:

978-3-659-11793-0

ISBN-10:
3659117935
EAN:
9783659117930
Langue du livre:
Anglais
texte du rabat:
Floating Drug Delivery Systems have emerged as an efficient means of enhancing the bioavailability and controlled delivery of Diltiazem hydrochloride. Drug absorption in the gastrointestinal tract is a highly variable processes and prolonging the gastric retention of dosage form via floating drug delivery system extends the time for drug absorption and ultimately increase bioavailability of drug. Diltiazem hydrochloride is a benzothiazepine-derivative calcium-channel blocker was chosen as a model drug due to its low oral bioavailability (30-40 %), short half-life (3 to 4 hrs), High frequency of dosing and low solubility at lower part of GI tract which makes it an appropriate candidate for a formulation in a sustained release floating drug delivery system, twice-a-day dosage form. The present study was aimed at designing a effervescent floating tablet of Diltiazem hydrochloride for controlled release of Diltiazem using different grades of Hydroxy propyl methyl cellulose such as HPMC K4M, HPMC K15M, HPMC K100M and Xanthan gum to achieve improved economy of tablet. Sodium bicarbonate and citric acid was used as a gas generating agent.
Maison d'édition:
LAP LAMBERT Academic Publishing
Site Web:
https://www.lap-publishing.com/
de (auteur) :
Aslam Siddiqui, Kiran Tapar, Shrikant Pande
Numéro de pages:
128
Publié le:
05-05-2012
Stock:
Disponible
Catégorie:
Pharmacie
Prix:
59.00 €
Mots-clés:
Floating Drug delivery System, Low absorption window drug, In-Vitro Buoyancy study, Mechanism of drug release

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