Couverture de Design and evaluation of solid dispersion of water insoluble drug
Titre du livre:

Design and evaluation of solid dispersion of water insoluble drug

LAP LAMBERT Academic Publishing (30-12-2015 )

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ISBN-13:

978-3-659-81645-1

ISBN-10:
3659816450
EAN:
9783659816451
Langue du livre:
Anglais
texte du rabat:
Improving oral bioavailability of drugs those given as solid dosage forms remains a challenge for the formulation scientists due to solubility problems. The dissolution rate could be the rate limiting process in the absorption of a drug from a solid dosage form of relatively insoluble drugs. Therefore increase in dissolution of poorly soluble drugs by solid dispersion technique presents a challenge to the formulation scientists. Solid dispersion techniques have attracted considerable interest of improving the dissolution rate of highly lipophilic drugs thereby improving their bioavailability by reducing drug particle size, improving wettability and forming amorphous particles. The term solid dispersion refers to a group of solid products consisting of at least two different components, generally a hydrophilic inert carrier or matrix and a hydrophobic drug. Solid dispersions demonstrated a higher dissolution rate than physical mixtures and pure drug. The solvent evaporation method of preparing solid dispersions was found to be satisfactory as it produced good product with high drug content. Out of the 18 formulations prepared, formulation A5 showed marked increase in the solubility
Maison d'édition:
LAP LAMBERT Academic Publishing
Site Web:
https://www.lap-publishing.com/
de (auteur) :
Vachaspati Dubey, Rashmi Kumari, B. D. Tripathi
Numéro de pages:
100
Publié le:
30-12-2015
Stock:
Disponible
Catégorie:
Autres
Prix:
54.90 €
Mots-clés:
DESIGN EVALUATION, solid dispersion, WATER INSOLUBLE DRUG

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