Couverture de CONTROLLED RELEASE FORMULATION OF ANTIHYPERTENSIVE DRUGS
Titre du livre:

CONTROLLED RELEASE FORMULATION OF ANTIHYPERTENSIVE DRUGS

Design and Optimization of Controlled Release Formulations for Calcium Channel Blockers

LAP LAMBERT Academic Publishing (09-05-2011 )

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ISBN-13:

978-3-8443-9241-8

ISBN-10:
3844392416
EAN:
9783844392418
Langue du livre:
Anglais
texte du rabat:
In present work an attempt has been made to improve to the therapeutic efficacy, systemic absorption of drug and patient compliance by developing extended release matrix tablet formulations of diltiazem HCl (DIL) and verapamil HCL (VER). DIL and VER matrix tablet formulations were prepared by direct compression by using various combination of HPMC K15M CR and Eudragit RSPO polymer. A full factorial design was applied to systematically optimize drug release profile. For optimization study and data analysis software OPTI – STAT was developed. The optimized formulations shows regression value for Higuchi kinetics indicated the diffusion dependence for drug release. Stability trials up to three months displayed excellent reproducibility. In vivo studies were carried out on the optimized batches and CF using new developed HPLC and LC-MS/MS methods A good correlation between the dissolution profiles and bioavailability indicated a linear relationship between in vitro – in vivo data.
Maison d'édition:
LAP LAMBERT Academic Publishing
Site Web:
https://www.lap-publishing.com/
de (auteur) :
Dr. Dheeraj Baviskar, Dr. R.B.Sharma, Dr. D.K.Jain
Numéro de pages:
324
Publié le:
09-05-2011
Stock:
Disponible
Catégorie:
Disciplines cliniques
Prix:
79.00 €
Mots-clés:
Diltiazem HCl; Verapamil HCL; Eudragit RSPO; Factorial design; HPLC; HPMC K15M CR; Optimization; Pharmacokinetics

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