Portada del libro de Xenobiotic metabolizing enzyme genes & esophageal & gastric cancers
Título del libro:

Xenobiotic metabolizing enzyme genes & esophageal & gastric cancers

Variation in xenobiotic metabolizing enzyme genes & susceptibility to esophageal & gastric cancers in Kashmir Valley

Scholars' Press (2014-05-21 )

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ISBN-13:

978-3-639-71138-7

ISBN-10:
3639711386
EAN:
9783639711387
Idioma del libro:
Inglés
Notas y citas / Texto breve:
The general theme of this book is to identify genetic variants of xenobiotic metabolizing enzyme genes associated with esophageal and gastric cancer susceptibility in Kashmir Valley. Genetic changes may impart growth advantage to cells by possible alteration in xenobiotic enzymes genes; the pivotal molecular machinery in the cell which controls whether a cell will proliferate, differentiate, become invasive and metastasize. Host metabolic enzymes and other protective proteins are known to protect against deleterious effects of carcinogens. Xenobiotic metabolizing enzymes are an important part of cellular enzymatic defense against endogenous and exogenous chemicals, many of which have carcinogenic potential. Most chemical carcinogens require metabolic activation by phase I enzymes (Cytochromes P-450) and detoxification by conjugation via the various phase II enzymes (epoxide hydrolase, glutathione S- transferase, N-Acetyl transferase, sulfo-transferase). The polymorphisms in genes for phase I and phase II enzymes are associated with inter-individual differences in susceptibility to environmentally induced cancers like esophageal and gastric cancer.
Editorial:
Scholars' Press
Sitio web:
http://www.scholars-press.com
Por (autor):
Manzoor Ahmad Malik
Número de páginas:
160
Publicado en:
2014-05-21
Stock:
Disponible
Categoría:
Genética
Precio:
79.90 €
Palabras clave:
polymorphism, PCR, Esophageal and Gastric cancer, Kashmir Valley, Gst, NAT2, Xenobiotic metabolizing enzymes., RFLP, CYP450

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