Portada del libro de Non-alcoholic fatty liver disease and drug toxicity
Título del libro:

Non-alcoholic fatty liver disease and drug toxicity

LAP LAMBERT Academic Publishing (2015-11-30 )

Books loader

Omni badge apto para el cupón
ISBN-13:

978-3-659-80713-8

ISBN-10:
3659807133
EAN:
9783659807138
Idioma del libro:
Inglés
Notas y citas / Texto breve:
Non-alcoholic fatty liver disease (NAFLD) is characterised by the accumulation of lipid in liver. Liver is the principal organ involved in drug biotransformation. The central hypothesis of this project is that alterations in the liver environment due to lipid accumulation aggravate sensitivity of hepatocytes to toxicity of some commonly prescribed drugs (paracetamol, alcohol, phenobarbital, cisplatin or doxorubicin). The aim of this study was to investigate the effect of lipid overloading (steatosis) on drug cytotoxicity in the liver model Huh7 cell line.The microarray data confirmed alterations in oxidative stress-related genes. Such changes were functionally relevant as confirmed by cellular assay and In-Cell Western blot. In conclusion, the hypothesised effect of steatosis on drug toxicity has been confirmed and steatosis may enhance drug toxicity through changing cellular oxidative state and activating the apoptotic pathway.
Editorial:
LAP LAMBERT Academic Publishing
Sitio web:
https://www.lap-publishing.com/
Por (autor):
Shareefa AlGhamdi
Número de páginas:
352
Publicado en:
2015-11-30
Stock:
Disponible
Categoría:
La bioquímica, la biofísica
Precio:
87.90 €
Palabras clave:
alcohol, Doxorubicin, drug, liver, NAFLD, oxidative stress, Paracetamol, toxicity

Books loader

Newsletter

Adyen::amex Adyen::mc Adyen::visa Adyen::cup Adyen::unionpay PayPal CryptoWallet Transferencia Bancaria

  0 productos en el carrito
Editar carrito
Loading frontend
LOADING