Portada del libro de Insulin Resistance and Nephropathy in Type 2 Diabetic Patients
Título del libro:
Insulin Resistance and Nephropathy in Type 2 Diabetic Patients
Insulin Resistance and Specific Biomarkers in Blood and Urine of Type 2 Diabetic Patients with or without Nephropathy
LAP LAMBERT Academic Publishing
(2020-11-23
)
apto para el cupón
ISBN-13:
978-620-3-04257-3
ISBN-10:
6203042579
EAN:
9786203042573
Idioma del libro:
Inglés
Notas y citas / Texto breve:
Diabetic nephropathy (DN) is a common and severe microvascular complication of type 2 diabetes mellitus (T2DM) that can result in end-stage renal disease (ESRD). On the other hand, insulin resistance (IR) is strongly associated with obesity and had an important role in the pathogenesis and increased complicating of many human diseases such as diabetes which can be used as a biomarker of renal dysfunction in DN thus decreasing the mortality and morbidity. Hence, taking into consideration the combination of obesity, IR and T2DM may demonstrated excellent indicator for early-stage DN in patients with T2DM. In the present study, we concluded that blood biomarkers (glucose, insulin, urea, creatinine, BMI, GFR, CrCl, IR, Hcy, FA, Cys C, LC, OPG, SA, Se, Zn, Mg) were emphatically connected with the nearness of nephropathy and they could be representing to indicators of renal impairment in DN. Moreover, Urinary Alb, NGAL, 8-OHdG and FN and the combination of all four biomarkers demonstrated an excellent diagnostic value for early-stage of DN in patients with T2DM. The above explored clinical biomarkers must be used later on for early recognition of DN in people of T2DM and its intricacy.